N3-PUFA Beneficial Only When Combined With Antioxidants

All of you who have been following this blog, lately, will have noticed that I tend to be skeptic whether fish oil and other PUFA supplements are recommendable without certain reservations. A recent study by Filaire et al. (Filaire. 2011) seems to support the view that poly-unsaturated fatty acids increase the potential for oxidative damage and should thus be combined with appropriate amounts of antioxidants to "compensate" this effect.

Over a period of 6 weeks the researchers supplemented a group of 36 judoists with either 600 mg EPA and 400 mg DHA per day or the same amount of long chain polyunsaturated fatty [LCPUFA] acids plus 30 mg vitamin E, 60 mg vitamin C and 6 mg β-carotene and measured resting and exercise-induced lipid peroxidation in their subjects. Here are the results:

At T (1) [before supplementation], there were no significant differences among treatment groups with respect to lipid peroxidation, lag phase, and levels of α-tocopherol or retinol. The consumption of an n-3 LC PUFA supplement increased oxidative stress at rest and did not attenuate the exercise-induced oxidative stress. The addition of antioxidants did not prevent the formation of oxidation products at rest. On the contrary, it seems that the combination of antioxidants added to the n-3 LCPUFA supplement led to a decrease in, CD(max) [conjugated dienes], R (max) [maximum rate of oxidation], and POOL [lipoperoxide ] and MDA [malondialdehyde] concentrations after a judo training session.

So, in a way LCPUFA work like "exercise in a pill": At rest, they increase similar stressors as exercise does. This holds true regardless of additional anti-oxidant supplementation. When you exercise, however, a combination of LCPUFA + antioxidants appears to provide some protection from exercise induced stressors, so that overall, athletes would probably benefit from LCPUFA + antioxidants consumption.

Notice, I purposefully wrote "consumption" and not "supplementation", because let's be honest: If we have a look at the combination of nutrients a natural diet would provide, you always get your LCPUFAs with adequate amounts of antioxidants. So, keeping or switching to a healthy diet should still be your priority - if you then still see the need for additional supplementation, you may want to give a quality fish oil and some vitamins a try.

Omega-3 Fatty Acids PRO(!)-Inflammatory in Athletes

Although I am aware of the magnitude of studies providing evidence for the positive effects of omega-3 fatty acids in general and EPA and DHA, in particular. I think you should be aware that research on its effects in athletes (as the general effect of anti-oxidants on healthy people) are less unequivocal than those on positive effects on your average pre-diabetic fatso.

In a very recent study, scientists from the Unité de Formation en Sciences et Techniques des Activités Physiques et Sportives in France (Filaire. 2010) found that judo athletes who took a standardized omega-3 supplement (600 mg EPA and 400 mg DHA) for 6 weeks had significantly increased stress markers compared to placebo:

Significant interaction effects between supplementation and time on resting MDA [malondyaldehide] concentrations and Rmax were found (p = .03 and p = .04, respectively), with elevated values in the n-3 LCPUFA group after supplementation and no change in the placebo group's levels. The authors observed a significantly greater NO and oxidative-stress increase with exercise (MDA, Rmax, CDmax, and NO) in the n-3 LCPUFA group than with placebo.

I've also read reports from (recreational) athletes all over the Internet claiming that whenever their PUFA supplementation goes beyond 1-2g per day, they start feeling drowsy, lose energy, recover slower and show other signs typically associated with increased inflammation. Feel free to use the comment function to let us know how fish oil or other omega3 sources make you feel.